Primary Investigator
Professor, Pathology and Laboratory Medicine and Pediatrics
Gay Crooks
Phone: (310) 206-0205
Fax: (310) 206-0356
610 Charles E. Young Drive East
Terasaki Life Sciences Building, Room 3014
Los Angeles, CA 90095
Gay M. Crooks is a Professor in the Departments of Pathology & Laboratory Medicine and Pediatrics in the David Geffen School of Medicine, UCLA. She is Co-director of the Broad Stem Cell Research Center and Co-Director of the Cancer and Stem Cell Biology Program, Jonsson Comprehensive Cancer Center at UCLA.
Dr Crooks graduated from medical school at the University of Western Australia and completed her FRACP (pediatrics) at Princess Margaret Hospital for Children prior to her fellowship training in Pediatric Hematology-Oncology at Childrens Hospital Los Angeles (CHLA). In 1993, she joined the faculty of the University of Southern California and established her laboratory and clinical programs in the Division of Research Immunology and Bone Marrow Transplantation at CHLA. In 2009 her research program moved to UCLA, where in addition to running her research program, Dr. Crooks is a pediatric bone marrow transplant physician in the Division of Pediatric Hematology-Oncology at UCLA Mattel Children's Hospital.
Selected Publications (of a total >90)
Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. Wu L, Petrigliano FA, Ba K, Lee S, Bogdanov J, McAllister DR, Adams JS, Rosenthal AK, Van Handel B, Crooks GM, Lin Y, Evseenko D. Osteoarthritis Cartilage. 2015 Feb;23(2):308-18. doi: 10.1016/j.joca.2014.11.012. Epub 2014 Nov 20. PMID: 25464168
A Reduced-Toxicity Regimen Is Associated with Durable Engraftment and Clinical Cure of Nonmalignant Genetic Diseases among Children Undergoing Blood and Marrow Transplantation with an HLA-Matched Related Donor. Mahadeo KM, Weinberg KI, Abdel-Azim H, Miklos DB, Killen R, Kohn D, Crooks GM, Shah AJ, Kharbanda S, Agarwal R, Kapoor N. Biol Blood Marrow Transplant. 2015 Mar;21(3):440-4. doi: 10.1016/j.bbmt.2014.11.005. Epub 2014 Nov 13. PMID: 25459642
Engineering the human thymic microenvironment to support thymopoiesis in vivo. Chung B, Montel-Hagen A, Ge S, Blumberg G, Kim K, Klein S, Zhu Y, Parekh C, Balamurugan A, Yang OO, Crooks GM. Stem Cells. 2014 Sep;32(9):2386-96. doi: 10.1002/stem.1731. PMID: 24801626
Human lymphoid development in the absence of common γ-chain receptor signaling. Kohn LA, Seet CS, Scholes J, Codrea F, Chan R, Zaidi-Merchant S, Zhu Y, De Oliveira S, Kapoor N, Shah A, Abdel-Azim H, Kohn DB, Crooks GM. J Immunol. 2014 Jun 1;192(11):5050-8. doi: 10.4049/jimmunol.1303496. Epub 2014 Apr 25. PMID: 24771849
Dynamics of HSPC repopulation in nonhuman primates revealed by a decade-long clonal-tracking study. Kim S, Kim N, Presson AP, Metzger ME, Bonifacino AC, Sehl M, Chow SA, Crooks GM, Dunbar CE, An DS, Donahue RE, Chen IS. Cell Stem Cell. 2014 Apr 3;14(4):473-85. doi: 10.1016/j.stem.2013.12.012. PMID: 24702996
Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling. Kim WS, Zhu Y, Deng Q, Chin CJ, He CB, Grieco AJ, Dravid GG, Parekh C, Hollis RP, Lane TF, Bouhassira EE, Kohn DB, Crooks GM. Stem Cells. 2014 Jun;32(6):1503-14. doi: 10.1002/stem.1677. PMID: 24677652
Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. Stem Cell Reports. 2013 Dec 12;1(6):575-89. doi: 10.1016/j.stemcr.2013.10.012. eCollection 2013. PMID: 24371811
Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, Zhu Y, Chan R, Dunn B, Crooks GM. PLoS One. 2013 May 16;8(5):e63718. doi: 10.1371/journal.pone.0063718. Print 2013. PMID: 23696850
Perivascular support of human hematopoietic stem/progenitor cells. Corselli M, Chin CJ, Parekh C, Sahaghian A, Wang W, Ge S, Evseenko D, Wang X, Montelatici E, Lazzari L, Crooks GM, Péault B. Blood. 2013 Apr 11;121(15):2891-901. doi: 10.1182/blood-2012-08-451864. Epub 2013 Feb 14. PMID: 23412095
Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy. Hsieh YT, Gang EJ, Geng H, Park E, Huantes S, Chudziak D, Dauber K, Schaefer P, Scharman C, Shimada H, Shojaee S, Klemm L, Parameswaran R, Loh M, Kang ES, Koo HH, Hofmann WK, Andrade J, Crooks GM, Willman CL, Müschen M, Papayannopoulou T, Heisterkamp N, Bönig H, Kim YM. Blood. 2013 Mar 7;121(10):1814-8. doi: 10.1182/blood-2012-01-406272. Epub 2013 Jan 14. PMID: 23319569
Critical differences in hematopoiesis and lymphoid development between humans and mice. Parekh C, Crooks GM. J Clin Immunol. 2013 May;33(4):711-5. doi: 10.1007/s10875-012-9844-3. Epub 2012 Dec 30. Review. PMID: 23274800
Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. PLoS One. 2012;7(10):e45603. doi: 10.1371/journal.pone.0045603. Epub 2012 Oct 9. Erratum in: PLoS One. 2012; 7(10): 10.1371/annotation/649fb8ef-a4c7-4ee7-b382-e1657b9aa07e. PMID: 23056209
Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans. Candotti F, Shaw KL, Muul L, Carbonaro D, Sokolic R, Choi C, Schurman SH, Garabedian E, Kesserwan C, Jagadeesh GJ, Fu PY, Gschweng E, Cooper A, Tisdale JF, Weinberg KI, Crooks GM, Kapoor N, Shah A, Abdel-Azim H, Yu XJ, Smogorzewska M, Wayne AS, Rosenblatt HM, Davis CM, Hanson C, Rishi RG, Wang X, Gjertson D, Yang OO, Balamurugan A, Bauer G, Ireland JA, Engel BC, Podsakoff GM, Hershfield MS, Blaese RM, Parkman R, Kohn DB. Blood. 2012 Nov 1;120(18):3635-46. doi: 10.1182/blood-2012-02-400937. Epub 2012 Sep 11. PMID: 22968453
Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin. Kohn LA, Hao QL, Sasidharan R, Parekh C, Ge S, Zhu Y, Mikkola HK, Crooks GM. Nat Immunol. 2012 Oct;13(10):963-71. doi: 10.1038/ni.2405. Epub 2012 Sep 2. PMID: 22941246
