Steven Bensinger, VMD, PhD
Metabolic regulation of immune function
Dr. Steven Bensinger's laboratory is focused on understanding how lipid metabolism influences the growth of rapidly dividing normal and neoplastic tissues. They have recently identified a cholesterol metabolic checkpoint that regulates cell cycle progression in a wide variety of normal and cancer cells. Key ongoing studies include elucidating the regulatory networks that control lipid biosynthetic program in normal cells, and how these networks become dysregulated in cancer. Other important studies in the laboratory focus on understanding how lipid signals alter immune responses, resulting in basic immune dysfunction and autoimmune diseases.
Tomas Ganz, MD, PhD
Iron homeostasis in health and disease
Iron is an essential trace element whose plasma concentrations must be maintained in a narrow range. Prolonged decrease in plasma iron concentration causes cellular iron deficiency and anemia, and prolonged increase causes iron toxicity leading to organ failure and death. Our group discovered the iron-regulatory hormone hepcidin and, together with others, characterized its effects, regulation and mechanism of action.
Wayne Grody, MD, PhD
Molecular genetics of metabolic and heritable neoplastic diseases
Utilizing modern molecular biologic techniques such as gene cloning, microarray hybridization, and gene transfer, my laboratory is involved in the elucidation, diagnosis and ultimately treatment of single-gene defects at the molecular level. Using human arginase deficiency, a defect in the urea cycle, as a model system, we are exploring, in close collaboration with the laboratory of Dr. Stephen Cederbaum, the molecular structure and tissue-specific regulation of the arginase genes in health and disease. More Info >>
Michael Teitell, MD, PhD
Signaling and epigenetics in immune system development and cancer
My laboratory studies two overlapping areas with emerging roles in cancer of the immune system. We initially compared gene expression profiles from B cell tumors that arose in immune deficient versus immune competent settings. This approach resulted in the isolation of a large number of differentially expressed genes. We have characterized these isolates and focused on members of the TCL1 gene family, which... More Info >>
Peter Tontonoz, MD, PhD
Transcriptional regulation of metabolism and inflammation
The nuclear hormone receptors are a family of ligand-activated transcription factors that play diverse roles in mammalian physiology. While it has long been recognized that these proteins are central to development and homeostasis in vertebrate organisms, recent work has begun to define an unexpected role for members of this superfamily in human disease. Obesity, diabetes and cardiovascular disease... More Info >>