The overall objectives of the Clinical Cytogenetics rotation are for the residents to be familiar with the basic techniques of chromosome preparation, banding, karyotype and Fluorescence In situ Hybridization (FISH) analysis, and some of the more common cytogenetics anomalies associated with genetic and neoplastic disease. During this period the resident will have opportunities to setup their own peripheral blood and perform analysis and learn the chromosome nomenclature, to know when the different cytogenetics tests are called for, and what the results mean vis-á-vis the disease. The resident will also have exposure to newer methods in molecular Cytogenetics such as multi-color FISH (m-FISH), and array Comparative Genomic Hybridization (aCGH). There will be ample opportunity to review abnormal cases and participate in lab meetings during the two-week rotation. A series of practical lectures under the supervision of Drs. Elizabeth Spiteri and Fabiola Quintero-Rivera will be given covering prenatal diagnosis, postnatal constitutional analysis, hematological disorders and solid tumors. Residents will have the opportunity to participate in the daily sign out with the directors. Finally, there will be opportunities for research and developmental projects.