The faculty at the Immunogenetics Center are involved in a number of research activities as listed below.
The UCLA Immunogenetics Center's assess the health of the human immune system using state of the art assays at the cellular, protein and gene expression level. The UCLA Immunogenetics Center's research efforts are focused on identifying the mechanisms underlying organ and tissue transplant rejection and developing diagnostic markers to identify patients at risk of rejection. The laboratory performs various tests including gene and protein expression, anti-HLA antibody production and T lymphocyte activation to assess the immune status of the patient and response to immunotherapy. The UCLA Immunogenetics Center provides state-of-the-art monitoring of immune responses in patients enrolled in clinical trials and for diagnostic purposes. The lab provides standardized immunological assays at the RNA, protein and cellular level to support clinical investigators in clarifying the association between immune monitoring assay results and clinical efficacy and response to therapy. In addition the laboratory performs further development of new technologies for immune assessment.
UCLA Immunogenetics Center performs class I and class II gene polymorphism testing for investigators studying the association between HLA and disease. UCLA immunogenetics Center performs MICA and KIR gene polymorphism testing for transplantation and disease association.
The UCLA Immunogenetics Center offers a variety of statistical modeling services to study factors influencing transplant outcome, assess the role of HLA genes in the development of disease, and characterize genetic and immune markers of rejection.
The UCLA Immunogenetics Center participates in studies aimed at understanding how polymorphisms in HLA molecules determine the nature of the antigenic peptides presented by HLA molecules and the application of this knowledge to vaccine development. The laboratory performs allele level typing of HLA-A, -B, -C, DRB and DQB loci to support vaccine development and clinical trials.
The UCLA Immunogenetics Center maintains a biological specimen repository for clinical and research use. Services include whole blood, lymphocyte and serum storage, EBV transformation, and nucleic acid isolation and storage.