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Translational Pathology Core Laboratory (TPCL)
The Translational Pathology Core Laboratory (TPCL) is housed within the Department of Pathology and Laboratory Medicine and is a UCLA Jonsson Comprehensive Cancer Center Shared Facility.
Since 1996, TPCL has provided an array of pathology related services in support of basic, translational and clinical research at UCLA. Our mission is to provide high quality pathology services in an efficient and cost-effective manner. TPCL also provides expert consultation services to investigators in pathology-related study design, tissue selection, microscopic interpretation, immunohistochemistry/in situ hybridization, laser capture microdissection, digital image analysis (including quantitative immunohistochemistry and immunofluorescence), and IRB-related tissue questions.
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Goals & Mission
The UCLA Translational Pathology Core Laboratory (TPCL) is a research facility in the Department of Pathology & Laboratory Medicine and the Jonsson Comprehensive Cancer Center dedicated to providing a variety of tissue-related services critical to the progress of biomedical research. The TPCL currently provides the following services:
- Tissue procurement (fresh, snap frozen, formalin-fixed)
- Tissue sectioning of frozen or paraffin-embedded tissueIHC/ISH
- Digital slide scanning and image analysis, including quantitative IHCLCM
- Pathology consultative services
- Advice on research protocols, safety issues, and IRB application
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Figure 1. Laser capture microdissection allows precise selection of cells (in this case,
the mantle zone area of a lymphoid follicle) for further molecular studies
