Assistant Professor, Pathology & Laboratory Medicine
Joshua Deignan, PhD, FACMG, is an Assistant Professor in the Department of Pathology and Laboratory Medicine in the David Geffen School of Medicine at UCLA. He is one of the Associate Directors of the UCLA Molecular Diagnostics Laboratories, specializing in the areas of molecular genetics and genomics. He performed his undergraduate work in Genetics at the University of California, Davis, and he received his Ph.D. in Pathology and completed his medical genetics fellowship training at UCLA. He is Board-certified by the American Board of Medical Genetics (Clinical Molecular Genetics) and is licensed by the state of California as a Clinical Genetic Molecular Biologist (CGMB).
Taylor S, Bennett KM, Deignan JL, Hendrix EC, Orton SM, Verma S, Schutzbank TE. Molecular pathology curriculum for medical laboratory scientists: a report of the association for molecular pathology training and education committee. J Mol Diagn. 2014 May;16(3):288-96. doi: 10.1016/j.jmoldx.2014.02.003.
Strom SP, Lee H, Das K, Vilain E, Nelson SF, Grody WW, Deignan JL. Assessing the necessity of confirmatory testing for exome-sequencing results in a clinical molecular diagnostic laboratory. Genet Med. 2014 Jan 9. doi: 10.1038/gim.2013.183.
Rehm HL, Bale SJ, Bayrak-Toydemir P, Berg JS, Brown KK, Deignan JL, Friez MJ, Funke BH, Hegde MR, Lyon E. ACMG clinical laboratory standards for next-generation sequencing. Working Group of the American College of Medical Genetics and Genomics Laboratory Quality Assurance Commitee. Genet Med. 2013 Sep;15(9):733-47. doi: 10.1038/gim.2013.92. Epub 2013 Jul 25.
Palmer CG, Boudreault P, Baldwin EE, Fox M, Deignan JL, Kobayashi Y, Sininger Y, Grody W, Sinsheimer JS. J Genet Couns. Deaf Genetic Testing and Psychological Well-Being in Deaf Adults. 2013 Feb 21.
Gallant NM, Leydiker K, Tang H, Feuchtbaum L, Lorey F, Puckett R, Deignan JL, Neidich J, Dorrani N, Chang E, Barshop BA, Cederbaum SD, Abdenur JE, Wang RY. Biochemical, molecular, and clinical characteristics of children with short chain acyl-CoA dehydrogenase deficiency detected by newborn screening in California. Mol Genet Metab. 2012 May;106(1):55-61. doi: 10.1016/j.ymgme.2012.02.007. Epub 2012 Feb 9.
Ong FS, Deignan JL, Kuo JZ, Bernstein KE, Rotter JI, Grody WW, Das K. Clinical utility of pharmacogenetic biomarkers in cardiovascular therapeutics: a challenge for clinical implementation. Pharmacogenomics. 2012 Mar;13(4):465-75. doi: 10.2217/pgs.12.2.
Ong FS, Grody WW, Deignan JL. Privacy and data management in the era of massively parallel next-generation sequencing. Expert Rev Mol Diagn. 2011 Jun;11(5):457-9. doi: 10.1586/ERM.11.34.
Deignan Joshua L, Grody Wayne W Ordering genetic tests and interpreting the results.. Advances in oto-rhino-laryngology. 2011; 70: 18-24.
Deignan Joshua L, De Deyn Peter P, Cederbaum Stephen D, Fuchshuber Arno, Roth Bernhard, Gsell Wieland, Marescau Bart Guanidino compound levels in blood, cerebrospinal fluid, and post-mortem brain material of patients with argininemia.. Molecular genetics and metabolism. 2010; 100 Suppl 1: S31-6.
Quintero-Rivera Fabiola, Deignan Joshua L, Peredo Jane, Grody Wayne W, Crandall Barbara, Sims Maureen, Cederbaum Stephen D An exon 1 deletion in OTC identified using chromosomal microarray analysis in a mother and her two affected deceased newborns: Implications for the prenatal diagnosis of ornithine transcarbamylase deficiency.. Molecular genetics and metabolism. 2010; .
Yang Xia, Peterson Larry, Thieringer Rolf, Deignan Joshua L, Wang Xuping, Zhu Jun, Wang Susanna, Zhong Hua, Stepaniants Serguei, Beaulaurier John, Wang I-Ming, Rosa Ray, Cumiskey Anne-Marie, Luo Jane Ming-Juan, Luo Qi, Shah Kashmira, Xiao Jianying, Nickle David, Plump Andrew, Schadt Eric E, Lusis Aldons J, Lum Pek Yee Identification and validation of genes affecting aortic lesions in mice.. The Journal of clinical investigation. 2010; .
Yang Xia, Deignan Joshua L, Qi Hongxiu, Zhu Jun, Qian Su, Zhong Judy, Torosyan Gevork, Majid Sana, Falkard Brie, Kleinhanz Robert R, Karlsson Jenny, Castellani Lawrence W, Mumick Sheena, Wang Kai, Xie Tao, Coon Michael, Zhang Chunsheng, Estrada-Smith Daria, Farber Charles R, Wang Susanna S, van Nas Atila, Ghazalpour Anatole, Zhang Bin, Macneil Douglas J, Lamb John R, Dipple Katrina M, Reitman Marc L, Mehrabian Margarete, Lum Pek Y, Schadt Eric E, Lusis Aldons J, Drake Thomas A Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.. Nature genetics. 2009; 41(4): 415-23.
Deignan Joshua L, Marescau Bart, Livesay Justin C, Iyer Ramaswamy K, De Deyn Peter P, Cederbaum Stephen D, Grody Wayne W Increased plasma and tissue guanidino compounds in a mouse model of hyperargininemia.. Molecular genetics and metabolism. 2008; 93(2): 172-8.
Deignan Joshua L, Cederbaum Stephen D, Grody Wayne W Contrasting features of urea cycle disorders in human patients and knockout mouse models.. Molecular genetics and metabolism. 2008; 93(1): 7-14.
Deignan Joshua L, Livesay Justin C, Yoo Paul K, Goodman Stephen I, O'Brien William E, Iyer Ramaswamy K, Cederbaum Stephen D, Grody Wayne W Ornithine deficiency in the arginase double knockout mouse.. Molecular genetics and metabolism. 2007; 89(1-2): 87-96.
Deignan Joshua L, Livesay Justin C, Shantz Lisa M, Pegg Anthony E, O'Brien William E, Iyer Ramaswamy K, Cederbaum Stephen D, Grody Wayne W Polyamine homeostasis in arginase knockout mice.. American journal of physiology. Cell physiology. 2007; 293(4): C1296-301.